Menthol 89-78-1 crystal Menthol

Model: j
Place of Origin: Tianjin,China (Mainland)
Brand Name: double
CAS No.: 89-78-1
Purity: 99.9

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:30.0 USDProduction Capacity:1000kgs
Trade Term:CFRPacking:alu foil bag
Payment Terms:WU, Money Gram, T/T, PaypalDelivery Date:3days
Min. Order:10 Gram
Means of Transport:Air

CHEMICAL NAME: DL-MENTHOL

CAS NO.: 89-78-1

MOLECULAR FORMULA: C10H20O

MOLECULAR WEIGHT: 156.27

Product Categories:Food additive.

best  quality  

Product Name:

DL-Menthol

Synonyms:

(1R,2S,5R)-rel-2-Isopropyl-5-Methylcyclohexanol;(+/-)-Menthol raceMic, >=98.0% (GC);menthol crystal extract;89-78-1;(1α,2β,5α)-5-methyl-2-(1-methylethyl)cyclohexanol;2-(1-methylethyl)-5-methyl-cyclohexanol;2-isopropyl-5-methyl-cyclohexano;5alpha-Methyl-2beta-(1alpha-methylethyl)cyclohexanol

CAS:

89-78-1

MF:

C10H20O

MW:

156.27

EINECS:

216-074-4

Product Categories:

phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized extract;Flavor & essential oil;Inhibitors;Monoterpenoids;Terpenes and Terpenoids (Isoprenoids);Alcohols;Building Blocks;C9 to C10;Chemical Synthesis;Nutrition Research;Ocimum basilicum (Basil);Organic Building Blocks;Oxygen Compounds;Phytochemicals by Chemical Classification;Phytochemicals by Plant (Food/Spice);Sambucus nigra (Elderberry);API Intermediate;chemical reagent;pharmaceutical intermediate

Mol File:

89-78-1.mol


 


DL-Menthol Chemical Properties

 

Melting point 

34-36 °C(lit.)

Boiling point 

216 °C(lit.)

alpha 

-2 º (c=10, EtOH)

density 

0.89 g/mL at 25 °C(lit.)

vapor pressure 

0.8 mm Hg ( 20 °C)

refractive index 

1.4615

FEMA 

2665 | MENTHOL RACEMIC

Fp 

200 °F

storage temp. 

Store below +30°C.

solubility 

456mg/l

form 

Crystalline Solid

color 

Colorless to white

Water Solubility 

insoluble

Merck 

14,5837

BRN 

3194263

CAS DataBase Reference

89-78-1(CAS DataBase Reference)

NIST Chemistry Reference

DL-Menthol(89-78-1)

EPA Substance Registry System

Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-(89-78-1)

 


Safety Information

 

Hazard Codes 

Xn,Xi

Risk Statements 

37/38-41-36/37/38

Safety Statements 

36/37/39-24/25-36-26-39

RIDADR 

UN 1888 6.1/PG 3

WGK Germany 

2

RTECS 

OT0350000

TSCA 

Yes

HS Code 

29061100

Hazardous Substances Data

89-78-1(Hazardous Substances Data)

 


MSDS Information

 

Provider

Language

p-Menthan-3-ol

English

 


DL-Menthol Usage And Synthesis

 

Flavors and fragrances

Menthol is a cyclic terpene alcohol flavors and fragrances with its appearance exhibiting colorless needle or shuttle columnar crystal or white crystalline powder. It has special aroma of mint with its taste being hot at first but then being cool later. It exhibit neutralizing reaction in the ethanol solution, being extremely easily soluble in ethanol, chloroform, petroleum ether, ether, liquid paraffin or volatile oil and being very slightly soluble in water. 
Its molecular structure contains three asymmetric carbon atoms, so it has four stereoisomers with their aroma intensity and type and cool feeling being different. There are two common types: natural menthol and synthetic menthol. Natural menthol is a kind of saturated ring alcohol obtained through the freezing & crystallization, separation and refinement of peppermint oil with the optical rotation being L; synthetic menthol is made from taking lemon eucalyptus oil as raw material. 
Its main component can be manufactured from the ring closing reaction of citronellal to obtain isopulegol, followed by hydrogenation, or through the synthesis of thymol from m-cresol with catalytic hydrogenation resulting in four menthol mixture of isomers with the precise vacuum distillation obtaining defined synthetic menthol, being racemate with no optical rotation. It has bactericidal and anti-corrosion effect and can be used as the fragrance of toothpaste, perfume, beverages and confectionery. In the medicine, it can be used for making cool oil, painkillers, mouthwash, and so on.
The main applications are as follows:
1. Menthol can act on the skin sensory nerve end, making the skin surface to produce cool feeling, achieving the purpose of itching prevention. Topical administration to the affected area can be used for the treatment of urticaria, prurigo, prickly heat, rash, neurodermatitis and skin pruritus and so on.
2. It can be used for the treatment of headache, nasal congestion and sore throat. This product has pleasant aroma and has curing effect on treating cold and wind heat. It has effects of refreshing the mind and clearing the throat.

First aid of poisoning

Topical application of menthol have effects of promoting blood circulation and anti-inflammatory, anti-itching and can be applied to anti-inflammatory, antipruritic, analgesic and reducing swelling and so on.
[Diagnosis]
1. Oral administration of large amount of menthol or inhaling of large amount of menthol gas can lead to gastrointestinal symptoms such as nausea, vomiting and abdominal pain as well as nervous system symptoms such as excitement, tremor, dizziness, vertigo, hand and foot numbness, swing gait, lethargy, breathing changes, facial flushing, reduced blood pressure, muscle rigidity or relaxation, occasional being not able to speak; children, after taking a large dose, can have coma. But it can be generally restored within a few hours.
2. Patients allergic to this chemical can get with eczema with unbearable itching feeling.
3. Small infants, sometimes due to nasal mint liquid or ointment, can get glottis spasm, accompanied with bruising and suffocation as well as secretion of large amounts of mucus. In severe cases, it may be occurred of respiratory and cardiac arrest.
[Treatment principles]
1. Gastric lavage; conduct catharsis with salt cathartic. Avoid using fats and oils.
2. Apply intravenous rehydration to promote excretion.
3. In cases of allergic symptoms, we should treat with antihistamines such as diphenhydramine, chlorpheniramine, etc.; if necessary, we can apply hydrocortisone or dexamethasone intravenously.

Detection method

(1) Chemical qualitative method
① take 1 g of this product, add 20 mL of sulfuric acids to dissolve it, so the reaction mixture becomes orange-red. After 24h, there will be colorless oil layer of non-menthol aroma precipitated out (the distinction from thymol).
② take 50 mg of this product, add 1mL of ice acetic acids to dissolve it; Addition of 6 drops of sulfuric acids  and 1 drop of nitric acids  to the cold mixture will lead to only slightly yellow color (the difference from thymol).
(2) thin-layer chromatography: take appropriate amount of menthol and dissolve in anhydrous ethanol, make a solution containing 6 mg menthol per mL for spotting. TLC: silica gel G manual plating, make it dry; have it subjected to activation in 105 °C for 1 hour and standby. Developing agent A: n-hexane-ethyl acetate-benzene (43: 4.5: 4); Developing agent B: petroleum-ether-ethyl acetate-chloroform (25: 2.5: 5.5). Coloration reagent: 5% vanillin ethanol solution-concentrated sulfuric acids  (100: 6). Coloration: heating at 105 ℃ for 6~10min, exhibiting a circular blue spots.
(3) Determination of physical constants: melting point: 42 ℃~44 °C. Specific rotation: take this product for accurately weighing; add ethanol to make a solution of 0.1 g/mL. Measure according to the method, the specific rotation is-49 ° ~-50 °.
(4) non-volatile matter: take 2 g of this product and place it in the pre-weighed evaporating dish; have it heated in the water bath so it is slowly evaporated; dried at 105 ℃ to constant weight with the leftover residue not exceeding 1mg.

Chemical properties

L-form appears as colorless needle crystal. The melting point is 42-43 °C; the boiling point is 216 °C, the specific rotation:-51 °-45 °; the flash point: 93 °C; the relative density: 0.8810; it is soluble in ethanol and is miscible with oil. It has cool, fresh, pleasant mint characteristic aroma with sweet spiky gas. It gives people a cold feeling with aroma penetrating through the hair, but not lasting. The taste is also fresh sweet cool taste.

Uses

It is mainly used in medicine, toothpaste, toothpaste and mouthwash with its cool taste being able to enhance the smell of peppermint oil, having effect of refreshing the brain as well as disinfection effects. It can also be used as spices to be applied to the colognes. Application of appropriate amount of low-grade soap and detergent fragrance such as roses, geraniol, lavender and fragrant has effects of enhancing the tone and aroma. It can also be applied to food flavors and flavor for wine and tobacco.
In medicine, it can be applied to the cooling oil, painkillers, etc., it can also be used for making toothpaste, toothpowder, candy, beverages, spices and so on. How to use: it can be used for formulating the food flavor in the food flavor plant; or also be directly added or dissolved in alcohol to be added to the food flavoring. Storage requirements: placed in a cool place, sealed for storage. Avoid wind and rain.

Chemical Properties

colorless to white crystalline solid

Uses

A chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.

Uses

In liqueurs, confectionery, perfumery, cigarettes, cough drops, and nasal inhalers.

General Description

White crystalline solid with a peppermint odor and taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

DL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers.

Fire Hazard

DL-Menthol is combustible.


Category: research chemical crystal


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